Monthly Archives: May 2012

TMA-6

1,3,5-Trimethoxyamphetamine or TMA-6 is psychedelic amphetamine. It is most closely related to mescaline, found in peyote, but has an alpha-methyl increasing potency and duration and a rearrangement of the methoxy groups on the ring.

TMA-6 Structure

It is a long-lived psychedelic with a duration between 12 and 16 hours taken orally, according to Shulgin. This is as expected due to the metabolic blockade provided by the ring substitutions and the a-methyl group. The oral dose is supposedly between 30 and 60 mg. Vaporised doses are typically 50-75% lower.

I returned one balmy afternoon to find a had some spare time and decided to attempt vaporising it. Vaporising allows superb dose control because of its fast onset, so you can easily decide when you have reached an acceptable level of intensity. It also offers a reduction in duration compared to oral of between /3 and 1/4. Substances with a longer duration are typically reduced less.

It is a beige-yellow solid. I had previously attempted and a/b extraction but this failed to remove the discolouration. there is a faint but pleasant essential oil type smell to it, perhaps from the alkene or aldehyde. the melting point is quoted as being high and this is corroborated by the fact that it takes a while to begin evaporating and burns slightly.

I loaded 26mg of the freebase into the vaporiser dissolved in 40% ethanol. I vape everything over about 20 minutes, noting that the larger breaths are quite unpleasant. I reach perhaps a 3/10, and although music sounds better there is no mood lift and no other strong effects. I load another 7mg and after trying for a bit decide I don’t really like it and wish I hadn’t bothered. My vision is almost cloudy, in a hard to describe manner.

I decide to re-read what Shulgin had to say on the matter. Upon remembering his experiences were high positive I am reassured that mine can be the same and I begin to enter a new frame full of cheer – the ever present importance of set and setting!

I move into some mild nausea which is not helped by eating, moving or being still. It is quite mild and easily ignored as I enjoy listening to music and going about my afternoon it fades to nothing within a few hours.

I have a think about where I am after about 2 hours and decide that I was probably more like a 4 before and am only now at a 3. The experience remains very pleasant, winding down very slowly. After 9 hours I am still around 2/10 and decide to have some weed to sleep. This brings on mild but colourful visuals and I am soon able to sleep.

Overall the experience was very pleasant and I am very keen to go again when I have the time for a 12 hour trip. Highly recommended.

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α-PVP

Alpha-Pyrrolidinopentiophenone has been around for a while but has made a recent resurgence as chinese labs churn out anything they think people will buy.

The long alpha chain increases potency through lipophilicity in pyrovalerones and α-PVP is no different. The dose is 10-20mg intranasal with things starting to get a bit intense above this.

As a pyrovalerone/prolintane derivative it is likely that α-PVP is an NDRI, which is consistent with its effects.

Overall I enjoyed using the drug but the crash was unpleasant and the sweet-spot is low due to the side-effects and crash being much more pronounced with redosing and higher doses. There is little euphoria to speak of and I suspect chasing it will end badly.

The first time I used it, I did so a little too much a little too late in the day. I turned to GBL to get to sleep 4 hours after the last dose and 4mls over an hour did not result in a sound slumber. Usually 3mls will have me out cold so I suspect there is strong, lingering NE activity.

Dose: 10-20mg followed by 10mg bumps. There are plenty of side effects which mean the sweet spot for a-PVP is relatively low.

The duration appears to be in the region of 3-5 hours depending on the dose.

Positive Effects:

  • Energy
  • Focus
  • Sociability
  • Increased sex drive
  • Mood lift
  • Increased music appreciation.
  • Nose-unblocking

Neutral effects

  • Minor pupil dilation
  • Urge to chew.
  • Slight mental cloudiness. Much less prominent than with other cathinones.
  • Membrane numbness

Negative effects

  • Sweating
  • Medium urge to redose
  • Unpleasant crash
  • Sleeplessness
  • Heart rate increase (67 went up to 80)
  • Minor vasoconstriction
  • Difficulty achieving erection.
  • Anxiety

α-PVP is illegal in the UK but unscheduled in the US.

Edit: I have revisited this now sometime later. In keeping with my comments about the low sweet spot I actually think that the recommended dose falls rather lower, and the recommendation should be more like 5-12mg. It is noticeably active below this too. 

As a compound it is frustrating because the side effects are unmanageable at high doses, which indicates that it is better to use at low, “functional” doses. Unfortunately, as with many cathinones it is a cloudy, slightly impairing high which means that it’s not particularly well suited to functional purposes either. I imagine it would be fine for basic tasks like cleaning or as an aphrodisiac but otherwise I don’t think I’d recommend it.