The NBOMe series is much newer to the world of science than many of the substances I’ve written about, which were often discovered decades ago and only recently revived by those looking to sell them. They were discovered in 2003 by Ralf Heim at the Freie Universität Berlin and consist of an o-methoxybenzyl moiety added to the amine of the psychedelic phenthylamines.
This relatively simple modification increases the potency of many in the 2C-X series by an order of magnitude, having activity in the microgram range. Perhaps fortunately, useful in preventing accidental ingestion, they are orally inactive because of the vulnerability of the N-benzyl bond to metabolism in the liver.Although the oral inactivity limits its ability to be misrepresented as LSD, this does seem to be occurring and it is worth noting that, as a phenthylamine, it is unlikely to have the same safety profile as LSD at higher doses. Already there are anecdotal reports of vasoconstriction, possible fatalities and my own research resulted in light-headedness and ataxia.
Dosage: 0.5 – 1mg nasally. 800-1.5mg buccally.
Duration: 8 hours
Description: A powerfully visual psychedelic with relatively less of the psychedelic headspace. This makes for a drug with good popular appeal.
I found this to have quite a dissociative note. When typing I felt much as I do after ample amounts of MXE and when I later went for a cycle, at one one point I thoroughly enjoyed chuckling to myself at the idea that I was a head being cycled along by an autonomous body acting without the need for instruction.
The visuals are very intense, OEVs plaster everything with beautiful fractals and tracers are quite intense. It is no wonder that 25I has a reputation for being quite visual.
The short comeup following nasal administration makes it quite suitable for staggered dosing, in my opinion. This would make it much easier to gauge the dose to give a pleasant, more gradual comeup and a more controlled plateau.
The headspace is very clear compared to others of the same intensity, and I feel like it was much more manageable and less introspective, especially considering the high dose. I agree with the assertion that this makes it quite suitable as a more recreational psychedelic.
I decided to dose this in a rather hurried manner as the evening was approaching and I intended to sleep on time. Without properly refreshing my memory about the dosage I prepared a solution of 2 mg/ml in 40% ethanol and used a dropping bottle to measure 1.3mg. I used a flame to evaporate the ethanol and insufflated the liquid.
Within a few minutes I felt the alerts and within 5 minutes there were clear visual distortions. I knew that I was in for an intense journey and suddenly clicked that I had taken a dose more suited to sublingual administration, and these were considerably higher than nasal due to swallowing.
Within 15 minutes visuals covered everything, and upon getting up to use the bathroom I found myself light-headed and slightly ataxic. I was somewhat disconcerted by the catapault comeup, concerned that I would be unfunctional for 6 hours with intensity rising for two and thought I might have miscalculated the dose somewhat more severely than the mix-up I had already noticed.
I was concerned for my wellbeing but in no state to act, so I put on some music and retired to my bed. The visuals were incredibly intense and there was a noticeable tension and bodyload in my legs, further worrying me, When I was able to escape my worries and challenging thoughts the music was absolutely glorious and the euphoria strong. At one point, following the drop in a song I felt every sensation accompanying a climax, except ejaculation and made a mental note that I should not use GHB to get to sleep later in case the euphoria was “too much”!
Upon next looking at the clock I realised an hour had gone by and the physical maladies had almost completely subsided. Reassured by my still being alive and the fact that the intensity did not seem to be increasing any more my mood lifted immediately. The rest of the trip was enjoyed thoroughly as any over, with the visuals merrily plastering everything they could and the tracers surprisingly intense.
Overall I would be very keen to use 25I again, although without a doubt at a lower dose. Perhaps 1.1mg alone or 0.8mg when tripping with others.