Monthly Archives: December 2012


NENK is a dissociative drug in the arylcyclohexamine class. SAR extrapolation suggests that it should be very similar to ketamine with an extended duration and increased potency as a result of the higher lipophilicity and enzyme resistance caused by the N-ethyl group. Given the two hour duration of ketamine, this modification was welcomed by ketamine users and the release was preceded by much hype.

The structure of NENK


Like the releases of many hyped NPSs though, it was met with much disappointment. Not only were the duration and potency worse than those of ketamine, it caused nosebleeds and had poorly comparable effects to boot. It is thought that retailers were all stocking from the same source laboratory, so initial speculation focused on the possibility of a low quality product, but when independent NMR spectra were released it appeared that it was indeed the real deal, with good apparent purity too, although it is possible that there is a very similar but inactive contaminant or that the NMR spectra are fake.

The nature of the poor reports involved an inherently low intensity, nasal burning, nosebleeds and a general lack of “warmth” experienced with ketamine. As a result of this I had not intended to try NENK, but after I performed an acetone wash on some for a colleague, he offered that I try it and I felt it might be worth seeing if the wash had made any difference.

The logic behind the acetone wash was that the synthesis might have produced an analogous impurity to the one which the DEA established could be produced in the synthesis of methoxetamine, but it is a good technique generally for possibly impure substances.

Dose (acetone washed): 45 mg

Duration: 1 Hour, Insufflated

Description: An impotent and generally unimpressive dissociative which is frankly not worth bothering with.

My Experience

The acetone wash was qualitative, with ~ 200 – 400 mg NENK placed in ~ 5 mls of acetone and heated. The acetone was discarded and the remaining 160mg of solid collected and dried. Solubility in the acetone did not seem good.

I initially insufflated approximately 15 mg up one nostril to gauge the intensity of the nasal discomfort and confirmed that even at this level, it was quite unpleasant. Within five minutes I suspected I could feel something and within ten minutes there was a distinct dissociative not. I decided to go for the whole experience so I insufflated some water as recommended by a member and then insufflated 26 mg of NENK between both nostrils. Again, the burn was unpleasant and significantly worse than other drugs in the class.

The dissociation I felt following this was not quite in line with the extra 170% dose but it was fairly pleasant nonetheless, perhaps comparable in intensity to about 15 mg of MXE. I have no low dose experience with ketamine to compare but it was significantly less intense than my lowest dose of 60 mg. I remained very functional the entire time and I would not have necessarily known it would lead to dissociation if I had never tried a dissociative before.

The effects began to wane after about 30 minutes and gave way to a “dissociative fuzz” about an hour later. I have experienced this before the day after large doses of other dissociatives but I would not have expected it from such a low-intensity experience. This remained until I slept 4 hours later, fading perhaps only by half. My nose was distinctly blocked and sniffly for the rest of the evening.

The next morning I awoke to find a considerable amount of dried blood in my nose, and again the next day. I used 2-FMA on this second day and went cycling at t+8 hours. About 20 minutes in I developed a pretty severe nosebleed which forced me to stop and then slowly cycle home. What’s interesting about this is that it was almost entirely in the nostril which I took the first line through, when it had not been moistened. Regardless of moisture there was also twice as much taken in this nostril. It is therefore possible that the damage is partly mechanical, although I am very skeptical of this. given the ease of moistening one’s nose before use I would say this is an essential practice.

I would absolutely not use NENK again, the mild effects and pathetic duration are not even slightly worth the nasal damage. It also appears to be more expensive than ketamine, giving it no recreational potential and frankly, almost none for a research chemical enthusiast either.