25I-NBOMe

Introduction:

The NBOMe series is much newer to the world of science than many of the substances I’ve written about, which were often discovered decades ago and only recently revived by those looking to sell them. They were discovered in 2003 by Ralf Heim at the Freie Universität Berlin and consist of an o-methoxybenzyl moiety added to the amine of the psychedelic phenthylamines.

This relatively simple modification increases the potency of many in the 2C-X series by an order of magnitude, having activity in the microgram range. Perhaps fortunately, useful in preventing accidental ingestion, they are orally inactive because of the vulnerability of the N-benzyl bond to metabolism in the liver.

Structure of 25I-NBOMe

2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine

Although the oral inactivity limits its ability to be misrepresented as LSD, this does seem to be occurring and it is worth noting that, as a phenthylamine, it is unlikely to have the same safety profile as LSD at higher doses. Already there are anecdotal reports of vasoconstriction, possible fatalities and my own research resulted in light-headedness and ataxia.

Dosage: 0.5 – 1mg nasally. 800-1.5mg buccally.

Duration: 8 hours

Description: A powerfully visual psychedelic with relatively less of the psychedelic headspace. This makes for a drug with good popular appeal.

Notes:

I found this to have quite a dissociative note. When typing I felt much as I do after ample amounts of MXE and when I later went for a cycle, at one one point I thoroughly enjoyed chuckling to myself at the idea that I was a head being cycled along by an autonomous  body acting without the need for instruction.

The visuals are very intense, OEVs plaster everything with beautiful fractals and tracers are quite intense. It is no wonder that 25I has a reputation for being quite visual.

The short comeup following nasal administration makes it quite suitable for staggered dosing, in my opinion. This would make it much easier to gauge the dose to give a pleasant, more gradual comeup and a more controlled plateau.

The headspace is very clear compared to others of the same intensity, and I feel like it was much more manageable and less introspective, especially considering the high dose. I agree with the assertion that this makes it quite suitable as a more recreational psychedelic.

Trip Report:

I decided to dose this in a rather hurried manner as the evening was approaching and I intended to sleep on time. Without properly refreshing my memory about the dosage I prepared a solution of 2 mg/ml in 40% ethanol and used a dropping bottle to measure 1.3mg. I used a flame to evaporate the ethanol and insufflated the liquid.

Within a few minutes I felt the alerts and within 5 minutes there were clear visual distortions. I knew that I was in for an intense journey and suddenly clicked that I had taken a dose more suited to sublingual administration, and these were considerably higher than nasal due to swallowing.

Within 15 minutes visuals covered everything, and upon getting up to use the bathroom I found myself light-headed and slightly ataxic. I was somewhat disconcerted by the catapault comeup, concerned that I would be unfunctional for 6 hours with intensity rising for two and thought I might have miscalculated the dose somewhat more severely than the mix-up I had already noticed.

I was concerned for my wellbeing but in no state to act, so I put on some music and retired to my bed. The visuals were incredibly intense and there was a noticeable tension and bodyload in my legs, further worrying me, When I was able to escape my worries and challenging thoughts the music was absolutely glorious and the euphoria strong. At one point, following the drop in a song I felt every sensation accompanying a climax, except ejaculation and made a mental note that I should not use GHB to get to sleep later in case the euphoria was “too much”!

Upon next looking at the clock I realised an hour had gone by and the physical maladies had almost completely subsided. Reassured by my still being alive and the fact that the intensity did not seem to be increasing any more my mood lifted immediately. The rest of the trip was enjoyed thoroughly as any over, with the visuals merrily plastering everything they could and the tracers surprisingly intense.

Overall I would be very keen to use 25I again, although without a doubt at a lower dose. Perhaps 1.1mg alone or 0.8mg when tripping with others.

Methylmethaqualone

Introduction:

Methylmethaqualone (MMQ) is a potent analogue of methaqualone (MQ), a depressant in the quaalude class. Methaqualone was popular recreationally until it was phased out of medical use in favour of the safer benzodiazepines. Since then supply has declined but recently a number of analogues have been produced.

MMQ is notably more potent than MQ, with little research surrounding its use in humans. Tests in mice indicated an increased tendency towards seizure and equipotency. Human experimentation has confirmed that seizures are possible at high doses.

Some concerns have been raised that its seizure induction suggests may be an AMPA agonist, meaning it would be excitotoxic and have an anti-nootropic effect, but having tried it once before hearing this and noticing no such effects I do not suspect this to be significant, if it is true at all.

Dosage: 12mg vaporised, 20mg sublingual, ~60mg(?) oral

Duration: 30 minutes vaporised, 90 minutes sublingual.

Description: A short active sedative with pleasant effects. Nothing particularly special

Notes:

I initially vaporised to get a feel for the effective dose. I loaded 12mg into the vaporiser. The HCl salt vaporises easily without burning. Constant inhalation is easy but large hits are horrible to inhale. The effects come on quickly and are typical of depressants. I noticed that it is somewhat more mood-lifting than benzodiazepines and has a bit more of a fun quality to it aside from the stardard anxiolytic effects of benzos. When I noticed my nose was bleeding I stopped vaporising immediately. I am not sure of the cause. The total duration can’t be more than 30 minutes.

The second trial was 18mg sublingually. The compound has a peculiar taste – not very bitter but almost sour, with a sting-y sort of taste. The after-taste is similarly odd. The effects come to a peak within around 20 minutes and are as before, pleasant. This peaked at about 20 mins and started to fade after 30. I would say it lasted about 2 hours total but I redosed 22mg after 1.5 hours as I found the original underwhelming. There were no adverse effects from this.

I tried this at a later date orally with no sublingual absorption. I initially dose 15mg, and while it was noticeable, it was very subtle. I added another two 15mg doses over the next hour and a half, but these added little. Fifteen minutes after these I added another 30mg which had a similarly small effect. I stopped at this point. This surprised me from the same batch as before, I wonder if the short duration indicates a fast metabolism and oral absorption is simply not fast enough to keep up with this in low doses. More research required.

Overall I would rate it well, if it is indeed not harmful. It is very pleasant with a duration just long enough to be suitable for a social setting.

TMA-6

1,3,5-Trimethoxyamphetamine or TMA-6 is psychedelic amphetamine. It is most closely related to mescaline, found in peyote, but has an alpha-methyl increasing potency and duration and a rearrangement of the methoxy groups on the ring.

TMA-6 Structure

It is a long-lived psychedelic with a duration between 12 and 16 hours taken orally, according to Shulgin. This is as expected due to the metabolic blockade provided by the ring substitutions and the a-methyl group. The oral dose is supposedly between 30 and 60 mg. Vaporised doses are typically 50-75% lower.

I returned one balmy afternoon to find a had some spare time and decided to attempt vaporising it. Vaporising allows superb dose control because of its fast onset, so you can easily decide when you have reached an acceptable level of intensity. It also offers a reduction in duration compared to oral of between /3 and 1/4. Substances with a longer duration are typically reduced less.

It is a beige-yellow solid. I had previously attempted and a/b extraction but this failed to remove the discolouration. there is a faint but pleasant essential oil type smell to it, perhaps from the alkene or aldehyde. the melting point is quoted as being high and this is corroborated by the fact that it takes a while to begin evaporating and burns slightly.

I loaded 26mg of the freebase into the vaporiser dissolved in 40% ethanol. I vape everything over about 20 minutes, noting that the larger breaths are quite unpleasant. I reach perhaps a 3/10, and although music sounds better there is no mood lift and no other strong effects. I load another 7mg and after trying for a bit decide I don’t really like it and wish I hadn’t bothered. My vision is almost cloudy, in a hard to describe manner.

I decide to re-read what Shulgin had to say on the matter. Upon remembering his experiences were high positive I am reassured that mine can be the same and I begin to enter a new frame full of cheer – the ever present importance of set and setting!

I move into some mild nausea which is not helped by eating, moving or being still. It is quite mild and easily ignored as I enjoy listening to music and going about my afternoon it fades to nothing within a few hours.

I have a think about where I am after about 2 hours and decide that I was probably more like a 4 before and am only now at a 3. The experience remains very pleasant, winding down very slowly. After 9 hours I am still around 2/10 and decide to have some weed to sleep. This brings on mild but colourful visuals and I am soon able to sleep.

Overall the experience was very pleasant and I am very keen to go again when I have the time for a 12 hour trip. Highly recommended.

α-PVP

Alpha-Pyrrolidinopentiophenone has been around for a while but has made a recent resurgence as chinese labs churn out anything they think people will buy.

The long alpha chain increases potency through lipophilicity in pyrovalerones and α-PVP is no different. The dose is 10-20mg intranasal with things starting to get a bit intense above this.

As a pyrovalerone/prolintane derivative it is likely that α-PVP is an NDRI, which is consistent with its effects.

Overall I enjoyed using the drug but the crash was unpleasant and the sweet-spot is low due to the side-effects and crash being much more pronounced with redosing and higher doses. There is little euphoria to speak of and I suspect chasing it will end badly.

The first time I used it, I did so a little too much a little too late in the day. I turned to GBL to get to sleep 4 hours after the last dose and 4mls over an hour did not result in a sound slumber. Usually 3mls will have me out cold so I suspect there is strong, lingering NE activity.

Dose: 10-20mg followed by 10mg bumps. There are plenty of side effects which mean the sweet spot for a-PVP is relatively low.

The duration appears to be in the region of 3-5 hours depending on the dose.

Positive Effects:

  • Energy
  • Focus
  • Sociability
  • Increased sex drive
  • Mood lift
  • Increased music appreciation.
  • Nose-unblocking

Neutral effects

  • Minor pupil dilation
  • Urge to chew.
  • Slight mental cloudiness. Much less prominent than with other cathinones.
  • Membrane numbness

Negative effects

  • Sweating
  • Medium urge to redose
  • Unpleasant crash
  • Sleeplessness
  • Heart rate increase (67 went up to 80)
  • Minor vasoconstriction
  • Difficulty achieving erection.
  • Anxiety

α-PVP is illegal in the UK but unscheduled in the US.

Edit: I have revisited this now sometime later. In keeping with my comments about the low sweet spot I actually think that the recommended dose falls rather lower, and the recommendation should be more like 5-12mg. It is noticeably active below this too. 

As a compound it is frustrating because the side effects are unmanageable at high doses, which indicates that it is better to use at low, “functional” doses. Unfortunately, as with many cathinones it is a cloudy, slightly impairing high which means that it’s not particularly well suited to functional purposes either. I imagine it would be fine for basic tasks like cleaning or as an aphrodisiac but otherwise I don’t think I’d recommend it.