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1-Propionyl-LSD

Introduction:

LSD is a classic and well known psychedelic drug known to be well tolerated physiologically by almost all users. Until recently very few analogues existed due to the relative difficulty of synthesising the lysergic acid backbone but in recent years constant scheduling of lower-hanging fruit has forced innovation in the novel psychoactive substance industry and a number of lysergamides have emerged as a result.

1-Acetyl-LSD (ALD-52) is somewhat notorious for its sale as “Orange Sunshine Acid” in California in the 1960s but has remained mysterious due to the theory that it might degrade to LSD combined with the slightly increased synthetic complexity putting off would-be chemists.

Despite being used to convict the manufacturers, the scientific principle behind this theory is incredibly unstable, with the acetyl group being used in laboratories around the world as a protecting group for indoles like LSD. Once attached, the group is resistant to removal except in extremely acidic or basic pH.

As a result of this rarity ALD-52 has never been confirmed as being sold and its activity has remained shrouded in mystery in recent times, with most assuming it to act as a pro-drug for LSD.

Despite this uncertainty and lack of sales the propionyl homologue has recently appeared on the market. This compound has not been reported on in any literature and is entirely unknown but given its similarity to LSD and ALD-52 the SAR reliably suggests an extremely similar effect profile.

1P-LSD

(6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

Qualitative discussion:

Despite the prevailing theory about 1P-LSD, it appears not to be an LSD pro-drug. It has both a shorter duration and an extremely close potency, two things which are rarely associated with a pro-drug, especially in combination.

The dose appeared to come on slightly slower than that of LSD but quickly built to full intensity following this. The subjective effects were very similar to those of LSD, perhaps with a slightly more disorientating come-up. The differences become evident around the five hour mark, where a distinct lessening of effects is evident. From here there is a gentle descent to sobriety over approximately 3-4 hours, giving a total duration of approximately 8-10 hours.

Pleasingly there appears to be little incidence of “body load”, unlike that seen with LSZ, whose duration is comparable. Despite the strong experience I had with this compound I found it easy to cope, more so than I would expect from LSZ. This makes it a preferable alternative for situations where introspection or spiritual experiences might not be appropriate.

According to Reagent Tests UK 1P-LSD gives a light purple reaction to the ehrlich reagent.

Dosage: 90-190ug orally (swallowed)

Duration: 8-10 hours

Description: A potent psychedelic which is difficult to distinguish from its popular analogue.

Notes:

Setting – close friend’s house with 3 friends for NYE party. Friends are vaporising DOC and plan to roll later in the evening.
Set – I recently ended a long term relationship and it is playing on my mind
Tolerance to this class of substances: 0/10 I have not tripped in several months.

1740: 166ug briefly chewed and swallowed on an empty stomach.

1800: I feel like something could be happening already
1810: Two housemates who do not use drugs come in before leaving and I’m able to make conversation pretty easily, though there is a lot of paraphernalia on the table and I am pleased to occupy myself with the mixing deck.
1820: The housemates leave and my friends comment that it was awkward as I believed.
1840: while trying to mix tracks I realise I am increasingly high
1850: I worry this might be too much! I take a break from DJing as I am not able to properly operate the system

1918: the level is actually really good as the comeup appears to be smoothing out
1923: Trembling quite a bit from a rocketship comeup. I am struggling to advise my friends on their taking of DOC
1934: Some gas/stomach discomfort – I am a little concerned that I may vomit
1941: I check my phone and put it in flight mode, realising I am way too high to effectively communicate with the outside world, even my closest friends who were not able to attend.
1946: I eat some porridge and a banana which settles my stomach, surprisingly
1950: I lay on the sofa for a bit enjoying my friend’s DJing and the visuals but am aware that this is higher than I wanted to be in this situation

2003: solid +++ now, strong visuals
2015: My friends try to get me to weigh their MDMA replacement for them and advise them on how much to take but my short term memory is terrible and I am really pretty useless, but somehow manage to get sensible doses into them.
2030: I decide the decks are a pleasant and familiar distraction and return to them.
2057: I am tripping very hard now but managing to make acceptable noises from the decks – though mostly just mixing tracks end to end.

2128: My friends’ roll mix is kicking in now but I’m not very good at making conversation

2233: Still a solid +++ and still playing on the decks

2300: certainly less high now than i was earlier

0023: MUCH more competent now, mixing is enjoyable again

0100: The two housemates return and one is a little boisterous. We manage to make conversation and keep them entertained before they retire to bed. I am pleased with my ability to cope but I am still distracting myself with the decks.
0147: Obviously on the way down now

0223: Very uncomfortable gas. very manageable level of tripping though.

0300: I am really hungry so I eat a family bag of crisps, a banana and quite a few peanuts.
0314: 15mg ketamine
0330: My gas has mostly passed, thank goodness

0430: I stop mixing and we put on some mixed sets from youtube
0449: Pretty much down now, I think it is only the ketamine that is noticeable.

0500: 5mg MXE

0620: After a little deliberation I take 0.5mg etizolam and go to bed. I fall asleep very rapidly and wake up at 1300 feeling fairly tired.

Conclusion:

Though the dose was too high for me in this setting I would repeat it in a heartbeat if I was alone and am keen to take a smaller dose with friends in the future. I would certainly stagger my doses over 15 minutes next time.
I think this will be a big seller as it has a very pleasant effects profile, is quite gentle and has minimal side effects/physical effects.

I expect this to rapidly gain popularity and be subsequently banned, a great shame considering the likely safety profile of this compared to other novel substances which have emerged in the last 5 years.

Lysergic Acid Dimethylazetidide (LSZ)

Introduction:

The lysergamides are perhaps the most famous of the synthetic psychedelic drugs, with LSD being the gold standard of the class. Though potent and legal analogues have been known for decades, the complexity of the synthesis seems to have ensured that only a minuscule number of humans have been able to sample them.

LSZ was originally investigated as a “constrained conformation” analogue of LSD, where the diethylamide moiety has been locked into the active conformation for binding to receptors. In vitro assays indicated it was more potent than LSD itself, one of a tiny fraction of compounds able to make this claim. While this does not appear to hold up in humans, LSZ is still a highly potent psychedelic which is strongly reminiscent of LSD.

Chemical structure of LSZ

(8β)-8-{[(2S,4S)-2,4-Dimethylazetidin-1-yl]carbonyl}-6-methyl-9,10-didehydroergoline

Its similar qualities may allow it to be passed off as LSD but it is likely that it has a similar safety profile and the “limited edition” nature of the compound makes it unlikely that most would bother to sell it as anything other than LSZ. It is certainly the rarest compound I’ve had the pleasure of sampling which is great but means that there is barely any existing information about the compound available.

Dosage: 150-300ug orally (swallowed)

Duration: 7-9 hours

Description: A classic psychedelic unsurprisingly reminiscent of its popular analogue.

Notes:

I was fortunate enough to see the analytical data for the compound and have every confidence that it is indeed LSZ. The blotters were officially laid with the structure on one side and “LSZ” on the other. They were completely tasteless.

The trip was very pleasant without too much in the way of challenging thoughts. It did seem to become a little more introspective towards the latter half but this was not unwelcome. The ease in keeping composure around the public, on the phone and even with people who were somewhat anti-drug is indicative of the relatively low intensity of the experience and as a fairly experienced tripper I would certainly go for 200ug next time, especially with a better setting.

The trip was comparable to 13 mg 2C-E, 700ug 25I NBOMe (nasal), or about 1.3 “hits” of LSD. The subjective effects were certainly most reminiscent of LSD and I’d wholeheartedly recommend LSZ to anyone interested in trying a shorter, more consistently dosed or less legally risky version of LSD. There was some stomach discomfort that I didn’t get on LSD but this would not put me off.

I would say the comeup was approx 45-60 mins to the first real alert, 3h to peak and the total duration perhaps 8h plus afterglow. With a higher dose it may reveal itself to be longer and come up a little faster as there were points at the beginning and end where I could not have said whether the subtle effects were a result of the LSZ or just placebo/afterglow.

Trip Report:

I had been keen to try LSZ for a while so managed to make time for it on a sunny day one weekend. Since there was little information available I was content with a relatively low dose (150ug), as much to understand the drug as to simply enjoy the experience. My girlfriend and I had her flat to ourselves until much later in the day and were mentally as well prepared as we might hope to have been. She took AL-LAD because she did not like the idea of taking such a novel substance.

We dosed late in the morning as I needed to catch a train that evening and within about 45 minutes I felt the first real alerts. After 1h15 I was unmistakeably hit by the experience and a sudden craving for some good music. I was sad to find her subwoofer was still broken and cursed myself for having left all my trip toys at my house but remained quite content to listen to music through the speakers she had. I did not find the music appreciation was as enhanced as with LSD itself but this may have been a function of the low dose.

Around the 2h mark I developed a mild stomach discomfort and ate a sandwich to fill myself and attempt to settle this. Though not really hungry I did enjoy the meal and the discomfort subsided in the following hour while we slowly gathered ourselves to find a nice spot in some fields a short walk away. I spoke to my girlfriend’s sister on the phone as my girlfriend did not want to and managed to to so with no problem at all. She did not suspect I was tripping until I said so towards the end of the conversation. We left the flat and walked down the high street, perfectly able to engage ourselves in normal conversation to keep from laughing.

We arrived at the fields to find they were boarded off to be developed into housing. Somewhat disappointed we walked a short way to an isolated churchyard and settled there. We stayed for about 4 hours chatting, listening to music and generally mucking about and having fun in the bright sun. The visual effects were pretty mild but textures were distorted as ever and it was occasionally possible to see fractal patterns in the grass or the sun coming through the trees.

Approximately 6.5 hours after dosing we returned to the flat where both my girlfriend’s sisters were. They were considerate of our fragile mental state but when their much more anti-drug boyfriends arrived to take them both out to dinner I was able to converse quite easily. After they left (t+7.5h) my girlfriend and I went to a nearby shop and bumped into some friends I’d rather not have. The experience was awkward and quietly played on my mind for the rest of the evening.

After eating the microwave meals we’d bought I felt nothing that couldn’t be put down to afterglow and easily got my train at t+11.5h. I slept fine a few hours later, though having gotten to bed late I was a little tired and irritable the next day.