2,5-Dimethoxy-4-chloroamphetamine (DOC) is long-lived, potent psychedelic which was discovered by Alexander Shulgin in the late 20th century. It has enjoyed a constant but low level of popularity although its high potency (3 mg dose) has meant it can generally only be handled in blotter form and as a result is sometimes dangerously misrepresented as LSD. As a psychedelic amphetamine it is regarded to be a stimulating psychedelic and is alleged to have an easygoing headspace and moderate visuals.
Although it has been around for a long time, there are few reports of any other ROA than oral, which surprised me given the marathon duration. I suspected that a shorter ROA would make the comeup shorter than the normal 2 hours and might make the total duration more manageable too. There were absolutely no reports of this but considering that vaporising the 2C-x series is very effective, I saw no reason it would not work for the closely related DOx series.
Dose: 1-5mg oral, 0.8-2.4 mg vaporised
Duration: 12-24 hours oral, 10-14 hours vaporised.
Description: A potent stimulating psychedelic with a very long comeup and long overall duration.
I spent the trip split between cycling and relaxing at home. I had plenty of energy for cycling and good focus without distractions, but never felt pushily energetic while relaxing. Music was certainly enhanced and the synaesthetic CEVs that came with it were wonderful. The trip was not very visual and very easy to handle so I suspect the dose could easily be pushed a little, although it certainly broke a mild +++ at the peak. I can see why it is popular as a party drug and if the duration was shorter I think it would enjoy much more popularity.
Vaporising provided a near-instant comeup, bypassed the stomach, gave excellent intensity control and did not burn. If the dose was well measured I would have every confidence vaporising over 20 minutes max ang gauging the intensity as I vaped to find a comfortable level, with the measured dosage providing a safety net. Unlike with vaporised 2C-xs the plateau was very nice and long which did not leave me with a desire to repeatedly redose. 2C-B has a 20 minute plateau vaped which makes it of little enjoyment as an ROA.
I weighed out 1.2 mg of DOC and placed it into my bulb vape, heating using a small candle. It quickly melted and began to vaporise without burning. The vapour was easy to inhale, even in “large” hits and the first alerts were present within a couple of minutes. I take a couple of good hits and the second comes with a psychedelic “rush” which takes me off-guard. I instantly wonder if I have overdone it and the nausea which I was suffering before plays on my mind.
I lie down and as the nausea subsides I notice I have slight tracers and music sounds good. I am trembling a little which does not surprise me. After a shower the physical sensations subside a little and I feel comfortable that I am not far above a ++ and would like some more. I finish the contents of the vape without any rushes this time. There is some jaw clenching and the visuals are a bit more distinct. Although the nausea does not return I feel physically uncomfortable again and lie down.
As I do so and close my eyes I begin to have synaesthetic visuals which flow perfectly with the music. They are beautiful but sadly not that intense. The visuals throughout the trip are pretty mild but can be brought out with focus. The time dilation is very significant but I am quite able to deal with it.
After about 45 minutes the uncomfortable sensations are gone and although not hungry I eat a banana. I then decide I’d like to go for a cycle so after a little deliberation about having to encounter other people I kit up and go. As I come to cross the main road I wait for what feels like quite a while. I notice the cars have minor tracers, making them appear like tron light-cycles and chuckle to myself. I feel quite able to cycle as soon as I get going and thoroughly enjoy meandering around a mix of mildly busy roads and totally empty country ones. When I stop of my own accord in country roads I feel incredibly peaceful but I really dislike stopping at traffic lights.
A friend comes round and we play call of duty for a while. I’m not as good as normal but still put up a good fight. After he leaves I have a balloon of nirtous. It is enjoyable as ever but I do not remember much of it and it just leaves me wanting more as always. I force a toasted sandwich which is actually pretty nice and I eat the other half about half an hour later. I appear to have come down considerably as I feel like I could much better handle speaking to others now.
I do another balloon and find the same results as before. I decide they would be better sipped slowly and find I am right as the balloon brings back a bit of intensity without being very shortlived.
I spend the rest of the evening chatting online and browsing the internet. 12 hours after the second dose I can still feel something but it’s not clear what. I certainly feel like I have come down almost completely. This feeling persists for 3 hours until I decide I have to try to sleep. I lie in bed and find myself falling asleep very quickly, even though there is music on and I have no sleep aids. I switch the music off and fall asleep near instantly. I awake the next morning after 9 hours and feel absolutely fine.
Overall a lovely experience which could have been easily enjoyed at a higher intensity. I felt about the same from t+12h onwards so probably could have slept from then. I never felt excessively stimulated but I imagine my body was well exercised from a 20 km cycle.
3-MeO-PCP is a dissociative drug in the arylcyclohexamine class. As the name suggests, it is related to PCP by the addition of a methoxy group. It is of similar potency, with doses in the 10mg region, but is more dissociative with less activity as a DRI. With a little luck, this will lead to less stimulation and mania, and therefore less of the crazy feats the PCP is infamous for.
The first mentions of 3-MeO-PCP seem to have come around mid 2009 with a few reports scattered around. Interest seemed to be piqued again as MXE gained popularity, but its rise has been stunted deliberately by responsible vendors ensuring it is not easily accessed. Given the accidents we are already seeing with other popular, potent drugs, this seems sensible.
It is supposed to be approximately 5x more potent than MXE. I think this is a good assessment, although higher doses are less impairing which can make it seem more like 3x potency. As someone who finds 30mg of MXE pretty ideal, I would say I most enjoy about 6mg of 3-MeO-PCP.
Duration: 7-8 Hours, Oral
Description: A potent yet remarkably lucid and functional dissociative, similar in feeling to methoxetamine. A little less mad and barely sleep-depriving compared to MXE’s slight ability to ward off sleep.
I quite enjoy potent drugs as there is less material to taste and they tend to be overlooked somewhat by those who don’t have the correct equipment to deal with them. I also quite enjoy methoxetamine, and given that this was described as a clearer, more recreational version of this I was excited to try it.
Upsettingly, there was little information available about the exact durations and doses , even by comparison to other drugs. I saw one comment suggesting that potency was about 5 x that of methoxetamine, but had also seen many reports suggesting that it was actually lower than this. Ignoring the comparison to MXE I decided to go for 3mg as a starter.
I knew this would be a very low dose, even sublingually. I dissolved it and quickly noticed a pleasant numbness, considerably stronger that that of MXE. The effects appeared slowly and reached a ceiling pretty quickly. there was a minor dissociative headspace but little more to speak of. Comfortable that I knew where the bar was set, I decided to try 10mg in the next trial.
I held the 10mg under my tongue for just under hour, with the numbness similar to pins and needles where the solution sat. This faded by about the 45 minute mark.
The effects came on quite quickly, with a pleasant headspace and mood lift being noticeable fairly quickly. As the intensity rose I found myself really enjoying music. It seemed less distorted than with MXE, although when it was off I noticed my hearing seemed muffled slightly, to a similar extent of that caused by MXE.
I found the effects to continue building well after I swallowed the sublingual solution, suggesting it is poorly absorbed in this way. After swallowing the plateau appeared to come after approximately one hour. It lasted for a solid 2 hours, until I ate dinner, at which point I felt the effects began to wane very smoothly and gradually. At t+6h there were still unmistakeable effects, but they were much reduced, to a point where I felt capable as if I were sober. I was tired, and upon going to bed I found that I had no problem getting to sleep.
The whole experience seemed to be very clear and lucid. Although I felt fairly dissociated, I was easily able to snap in and out while typing, and the amnesic and visual fog which I get on others did not seem to be so present. There were also many of the introspective thoughts about my life, society and the future which I associate with MXE. I have always found these thoughts to be akin to the stereotypical ones expected but not obtained from classical psychedelics.
The similarities to ketamine are few and far between, with much less cognitive inhibition, sedation and ataxia by comparison.
Overall, very enjoyable, and certainly one I will repeat. I do not think its effects are worthy of a 10x price increase over MXE though.
The NBOMe series is much newer to the world of science than many of the substances I’ve written about, which were often discovered decades ago and only recently revived by those looking to sell them. They were discovered in 2003 by Ralf Heim at the Freie Universität Berlin and consist of an o-methoxybenzyl moiety added to the amine of the psychedelic phenthylamines.
This relatively simple modification increases the potency of many in the 2C-X series by an order of magnitude, having activity in the microgram range. Perhaps fortunately, useful in preventing accidental ingestion, they are orally inactive because of the vulnerability of the N-benzyl bond to metabolism in the liver.Although the oral inactivity limits its ability to be misrepresented as LSD, this does seem to be occurring and it is worth noting that, as a phenthylamine, it is unlikely to have the same safety profile as LSD at higher doses. Already there are anecdotal reports of vasoconstriction, possible fatalities and my own research resulted in light-headedness and ataxia.
Dosage: 0.5 – 1mg nasally. 800-1.5mg buccally.
Duration: 8 hours
Description: A powerfully visual psychedelic with relatively less of the psychedelic headspace. This makes for a drug with good popular appeal.
I found this to have quite a dissociative note. When typing I felt much as I do after ample amounts of MXE and when I later went for a cycle, at one one point I thoroughly enjoyed chuckling to myself at the idea that I was a head being cycled along by an autonomous body acting without the need for instruction.
The visuals are very intense, OEVs plaster everything with beautiful fractals and tracers are quite intense. It is no wonder that 25I has a reputation for being quite visual.
The short comeup following nasal administration makes it quite suitable for staggered dosing, in my opinion. This would make it much easier to gauge the dose to give a pleasant, more gradual comeup and a more controlled plateau.
The headspace is very clear compared to others of the same intensity, and I feel like it was much more manageable and less introspective, especially considering the high dose. I agree with the assertion that this makes it quite suitable as a more recreational psychedelic.
I decided to dose this in a rather hurried manner as the evening was approaching and I intended to sleep on time. Without properly refreshing my memory about the dosage I prepared a solution of 2 mg/ml in 40% ethanol and used a dropping bottle to measure 1.3mg. I used a flame to evaporate the ethanol and insufflated the liquid.
Within a few minutes I felt the alerts and within 5 minutes there were clear visual distortions. I knew that I was in for an intense journey and suddenly clicked that I had taken a dose more suited to sublingual administration, and these were considerably higher than nasal due to swallowing.
Within 15 minutes visuals covered everything, and upon getting up to use the bathroom I found myself light-headed and slightly ataxic. I was somewhat disconcerted by the catapault comeup, concerned that I would be unfunctional for 6 hours with intensity rising for two and thought I might have miscalculated the dose somewhat more severely than the mix-up I had already noticed.
I was concerned for my wellbeing but in no state to act, so I put on some music and retired to my bed. The visuals were incredibly intense and there was a noticeable tension and bodyload in my legs, further worrying me, When I was able to escape my worries and challenging thoughts the music was absolutely glorious and the euphoria strong. At one point, following the drop in a song I felt every sensation accompanying a climax, except ejaculation and made a mental note that I should not use GHB to get to sleep later in case the euphoria was “too much”!
Upon next looking at the clock I realised an hour had gone by and the physical maladies had almost completely subsided. Reassured by my still being alive and the fact that the intensity did not seem to be increasing any more my mood lifted immediately. The rest of the trip was enjoyed thoroughly as any over, with the visuals merrily plastering everything they could and the tracers surprisingly intense.
Overall I would be very keen to use 25I again, although without a doubt at a lower dose. Perhaps 1.1mg alone or 0.8mg when tripping with others.
1,3,5-Trimethoxyamphetamine or TMA-6 is psychedelic amphetamine. It is most closely related to mescaline, found in peyote, but has an alpha-methyl increasing potency and duration and a rearrangement of the methoxy groups on the ring.
It is a long-lived psychedelic with a duration between 12 and 16 hours taken orally, according to Shulgin. This is as expected due to the metabolic blockade provided by the ring substitutions and the a-methyl group. The oral dose is supposedly between 30 and 60 mg. Vaporised doses are typically 50-75% lower.
I returned one balmy afternoon to find a had some spare time and decided to attempt vaporising it. Vaporising allows superb dose control because of its fast onset, so you can easily decide when you have reached an acceptable level of intensity. It also offers a reduction in duration compared to oral of between /3 and 1/4. Substances with a longer duration are typically reduced less.
It is a beige-yellow solid. I had previously attempted and a/b extraction but this failed to remove the discolouration. there is a faint but pleasant essential oil type smell to it, perhaps from the alkene or aldehyde. the melting point is quoted as being high and this is corroborated by the fact that it takes a while to begin evaporating and burns slightly.
I loaded 26mg of the freebase into the vaporiser dissolved in 40% ethanol. I vape everything over about 20 minutes, noting that the larger breaths are quite unpleasant. I reach perhaps a 3/10, and although music sounds better there is no mood lift and no other strong effects. I load another 7mg and after trying for a bit decide I don’t really like it and wish I hadn’t bothered. My vision is almost cloudy, in a hard to describe manner.
I decide to re-read what Shulgin had to say on the matter. Upon remembering his experiences were high positive I am reassured that mine can be the same and I begin to enter a new frame full of cheer – the ever present importance of set and setting!
I move into some mild nausea which is not helped by eating, moving or being still. It is quite mild and easily ignored as I enjoy listening to music and going about my afternoon it fades to nothing within a few hours.
I have a think about where I am after about 2 hours and decide that I was probably more like a 4 before and am only now at a 3. The experience remains very pleasant, winding down very slowly. After 9 hours I am still around 2/10 and decide to have some weed to sleep. This brings on mild but colourful visuals and I am soon able to sleep.
Overall the experience was very pleasant and I am very keen to go again when I have the time for a 12 hour trip. Highly recommended.