Desoxypipradrol (2-DPMP) is long-lived, potent stimulant which was released in the wake of the UK cathinone ban as a possible substitute for the banned substances. It quickly grew a fearsome reputation as an incredibly long lived stimulant with little to no euphoria and not much recreational potential at all. It also emerged as the ingredient in “Ivory Wave” which caused a number of psychotic hospitalisations, presumably as a result of people chasing the euphoria.
Unsurprisingly it quickly fell to the sidelines, although it was not forgotten, with the UK government banning import in December 2011. It was finally scheduled as a class B drug in May 2012.
The effects are very subtle at any dose worth trying, and useful but horribly drawn out at doses above this. In my opinion it has no recreational value. Interestingly for a DRI I did not notice a comedown.
Dose: 4mg orally
Duration: 16-72 hours
Description: A potent functional stimulant with a gruelling duration and long come-up.
Due to the low dose I made up a volumetric solution into 5 mg blotters and ate one. I experienced nothing the entire day and slept fine.
The next day I figured that I would still have some of yesterday’s dose and if I had the same again they would stack to a threshold dose. I dosed early again and felt nothing until about 10pm. I noticed I had some jaw tension which built over the following hours. I was not tired and did not bother trying to sleep for 2 hours past my normal time. I tried in vain until about 4am, when I dosed enough GBL to knock myself out until 8am. That day my focus was excellent, but my heart rate was up 20 BPM and I could feel it beating when I was sat quietly.
I was quite tired the next night, but still needed GBL to get any sleep. This portion was slightly fun, but that was no fault of the DPMP.
My heart rate was still high on this, the fourth day after dose 1, but my focus was normal. By the time night came I was able to sleep naturally and my BPM was normal again.
I tried 2-DPMP a few more times, but never once found it to be useful without also disrupting my sleep. Even when vaporised it cause problems. I do not think I would bother with it again. The come-up and duration are too long and it is too unpredictable.
3-MeO-PCP is a dissociative drug in the arylcyclohexamine class. As the name suggests, it is related to PCP by the addition of a methoxy group. It is of similar potency, with doses in the 10mg region, but is more dissociative with less activity as a DRI. With a little luck, this will lead to less stimulation and mania, and therefore less of the crazy feats the PCP is infamous for.
The first mentions of 3-MeO-PCP seem to have come around mid 2009 with a few reports scattered around. Interest seemed to be piqued again as MXE gained popularity, but its rise has been stunted deliberately by responsible vendors ensuring it is not easily accessed. Given the accidents we are already seeing with other popular, potent drugs, this seems sensible.
It is supposed to be approximately 5x more potent than MXE. I think this is a good assessment, although higher doses are less impairing which can make it seem more like 3x potency. As someone who finds 30mg of MXE pretty ideal, I would say I most enjoy about 6mg of 3-MeO-PCP.
Duration: 7-8 Hours, Oral
Description: A potent yet remarkably lucid and functional dissociative, similar in feeling to methoxetamine. A little less mad and barely sleep-depriving compared to MXE’s slight ability to ward off sleep.
I quite enjoy potent drugs as there is less material to taste and they tend to be overlooked somewhat by those who don’t have the correct equipment to deal with them. I also quite enjoy methoxetamine, and given that this was described as a clearer, more recreational version of this I was excited to try it.
Upsettingly, there was little information available about the exact durations and doses , even by comparison to other drugs. I saw one comment suggesting that potency was about 5 x that of methoxetamine, but had also seen many reports suggesting that it was actually lower than this. Ignoring the comparison to MXE I decided to go for 3mg as a starter.
I knew this would be a very low dose, even sublingually. I dissolved it and quickly noticed a pleasant numbness, considerably stronger that that of MXE. The effects appeared slowly and reached a ceiling pretty quickly. there was a minor dissociative headspace but little more to speak of. Comfortable that I knew where the bar was set, I decided to try 10mg in the next trial.
I held the 10mg under my tongue for just under hour, with the numbness similar to pins and needles where the solution sat. This faded by about the 45 minute mark.
The effects came on quite quickly, with a pleasant headspace and mood lift being noticeable fairly quickly. As the intensity rose I found myself really enjoying music. It seemed less distorted than with MXE, although when it was off I noticed my hearing seemed muffled slightly, to a similar extent of that caused by MXE.
I found the effects to continue building well after I swallowed the sublingual solution, suggesting it is poorly absorbed in this way. After swallowing the plateau appeared to come after approximately one hour. It lasted for a solid 2 hours, until I ate dinner, at which point I felt the effects began to wane very smoothly and gradually. At t+6h there were still unmistakeable effects, but they were much reduced, to a point where I felt capable as if I were sober. I was tired, and upon going to bed I found that I had no problem getting to sleep.
The whole experience seemed to be very clear and lucid. Although I felt fairly dissociated, I was easily able to snap in and out while typing, and the amnesic and visual fog which I get on others did not seem to be so present. There were also many of the introspective thoughts about my life, society and the future which I associate with MXE. I have always found these thoughts to be akin to the stereotypical ones expected but not obtained from classical psychedelics.
The similarities to ketamine are few and far between, with much less cognitive inhibition, sedation and ataxia by comparison.
Overall, very enjoyable, and certainly one I will repeat. I do not think its effects are worthy of a 10x price increase over MXE though.
The NBOMe series is much newer to the world of science than many of the substances I’ve written about, which were often discovered decades ago and only recently revived by those looking to sell them. They were discovered in 2003 by Ralf Heim at the Freie Universität Berlin and consist of an o-methoxybenzyl moiety added to the amine of the psychedelic phenthylamines.
This relatively simple modification increases the potency of many in the 2C-X series by an order of magnitude, having activity in the microgram range. Perhaps fortunately, useful in preventing accidental ingestion, they are orally inactive because of the vulnerability of the N-benzyl bond to metabolism in the liver.Although the oral inactivity limits its ability to be misrepresented as LSD, this does seem to be occurring and it is worth noting that, as a phenthylamine, it is unlikely to have the same safety profile as LSD at higher doses. Already there are anecdotal reports of vasoconstriction, possible fatalities and my own research resulted in light-headedness and ataxia.
Dosage: 0.5 – 1mg nasally. 800-1.5mg buccally.
Duration: 8 hours
Description: A powerfully visual psychedelic with relatively less of the psychedelic headspace. This makes for a drug with good popular appeal.
I found this to have quite a dissociative note. When typing I felt much as I do after ample amounts of MXE and when I later went for a cycle, at one one point I thoroughly enjoyed chuckling to myself at the idea that I was a head being cycled along by an autonomous body acting without the need for instruction.
The visuals are very intense, OEVs plaster everything with beautiful fractals and tracers are quite intense. It is no wonder that 25I has a reputation for being quite visual.
The short comeup following nasal administration makes it quite suitable for staggered dosing, in my opinion. This would make it much easier to gauge the dose to give a pleasant, more gradual comeup and a more controlled plateau.
The headspace is very clear compared to others of the same intensity, and I feel like it was much more manageable and less introspective, especially considering the high dose. I agree with the assertion that this makes it quite suitable as a more recreational psychedelic.
I decided to dose this in a rather hurried manner as the evening was approaching and I intended to sleep on time. Without properly refreshing my memory about the dosage I prepared a solution of 2 mg/ml in 40% ethanol and used a dropping bottle to measure 1.3mg. I used a flame to evaporate the ethanol and insufflated the liquid.
Within a few minutes I felt the alerts and within 5 minutes there were clear visual distortions. I knew that I was in for an intense journey and suddenly clicked that I had taken a dose more suited to sublingual administration, and these were considerably higher than nasal due to swallowing.
Within 15 minutes visuals covered everything, and upon getting up to use the bathroom I found myself light-headed and slightly ataxic. I was somewhat disconcerted by the catapault comeup, concerned that I would be unfunctional for 6 hours with intensity rising for two and thought I might have miscalculated the dose somewhat more severely than the mix-up I had already noticed.
I was concerned for my wellbeing but in no state to act, so I put on some music and retired to my bed. The visuals were incredibly intense and there was a noticeable tension and bodyload in my legs, further worrying me, When I was able to escape my worries and challenging thoughts the music was absolutely glorious and the euphoria strong. At one point, following the drop in a song I felt every sensation accompanying a climax, except ejaculation and made a mental note that I should not use GHB to get to sleep later in case the euphoria was “too much”!
Upon next looking at the clock I realised an hour had gone by and the physical maladies had almost completely subsided. Reassured by my still being alive and the fact that the intensity did not seem to be increasing any more my mood lifted immediately. The rest of the trip was enjoyed thoroughly as any over, with the visuals merrily plastering everything they could and the tracers surprisingly intense.
Overall I would be very keen to use 25I again, although without a doubt at a lower dose. Perhaps 1.1mg alone or 0.8mg when tripping with others.