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NENK is a dissociative drug in the arylcyclohexamine class. SAR extrapolation suggests that it should be very similar to ketamine with an extended duration and increased potency as a result of the higher lipophilicity and enzyme resistance caused by the N-ethyl group. Given the two hour duration of ketamine, this modification was welcomed by ketamine users and the release was preceded by much hype.

The structure of NENK


Like the releases of many hyped NPSs though, it was met with much disappointment. Not only were the duration and potency worse than those of ketamine, it caused nosebleeds and had poorly comparable effects to boot. It is thought that retailers were all stocking from the same source laboratory, so initial speculation focused on the possibility of a low quality product, but when independent NMR spectra were released it appeared that it was indeed the real deal, with good apparent purity too, although it is possible that there is a very similar but inactive contaminant or that the NMR spectra are fake.

The nature of the poor reports involved an inherently low intensity, nasal burning, nosebleeds and a general lack of “warmth” experienced with ketamine. As a result of this I had not intended to try NENK, but after I performed an acetone wash on some for a colleague, he offered that I try it and I felt it might be worth seeing if the wash had made any difference.

The logic behind the acetone wash was that the synthesis might have produced an analogous impurity to the one which the DEA established could be produced in the synthesis of methoxetamine, but it is a good technique generally for possibly impure substances.

Dose (acetone washed): 45 mg

Duration: 1 Hour, Insufflated

Description: An impotent and generally unimpressive dissociative which is frankly not worth bothering with.

My Experience

The acetone wash was qualitative, with ~ 200 – 400 mg NENK placed in ~ 5 mls of acetone and heated. The acetone was discarded and the remaining 160mg of solid collected and dried. Solubility in the acetone did not seem good.

I initially insufflated approximately 15 mg up one nostril to gauge the intensity of the nasal discomfort and confirmed that even at this level, it was quite unpleasant. Within five minutes I suspected I could feel something and within ten minutes there was a distinct dissociative not. I decided to go for the whole experience so I insufflated some water as recommended by a member and then insufflated 26 mg of NENK between both nostrils. Again, the burn was unpleasant and significantly worse than other drugs in the class.

The dissociation I felt following this was not quite in line with the extra 170% dose but it was fairly pleasant nonetheless, perhaps comparable in intensity to about 15 mg of MXE. I have no low dose experience with ketamine to compare but it was significantly less intense than my lowest dose of 60 mg. I remained very functional the entire time and I would not have necessarily known it would lead to dissociation if I had never tried a dissociative before.

The effects began to wane after about 30 minutes and gave way to a “dissociative fuzz” about an hour later. I have experienced this before the day after large doses of other dissociatives but I would not have expected it from such a low-intensity experience. This remained until I slept 4 hours later, fading perhaps only by half. My nose was distinctly blocked and sniffly for the rest of the evening.

The next morning I awoke to find a considerable amount of dried blood in my nose, and again the next day. I used 2-FMA on this second day and went cycling at t+8 hours. About 20 minutes in I developed a pretty severe nosebleed which forced me to stop and then slowly cycle home. What’s interesting about this is that it was almost entirely in the nostril which I took the first line through, when it had not been moistened. Regardless of moisture there was also twice as much taken in this nostril. It is therefore possible that the damage is partly mechanical, although I am very skeptical of this. given the ease of moistening one’s nose before use I would say this is an essential practice.

I would absolutely not use NENK again, the mild effects and pathetic duration are not even slightly worth the nasal damage. It also appears to be more expensive than ketamine, giving it no recreational potential and frankly, almost none for a research chemical enthusiast either.



Mebroqualone (MBQ) is another attempt to capture the popularity of methaqualone with an unscheduled analogue. It seems very rare, with no available reports but some mention of prior appearances on the grey market. As with its relatives, it is likely that MBQ is a GABA agonist and appears to be fairly potent, similar to methylmethaqualone (MMQ). This is strange given the “normal” potency of mecloqualone in the 100mg range.

Mebroqualone structure


The effects seem similar to those that methaqualone is reputed for, a pleasant disorientation and depressant effect, going a little further than the simple anxiolytic and sedative effects of benzodiazepines. This makes it a little more fun, and coupled with the short duration this could make it quite suitable for a party setting if it is similarly active orally.

Dose: 15-20mg sublingually

Duration: 60 minutes

Description: A potent yet short-lived quaalude. The depressant effects are quite pleasant, making the short duration a shame.

My Experiences

Being initially quite unsure of the dosage, I worked up very slowly with this. It emerged that it was active in the same range as MMQ, but perhaps with a slightly shorter duration. Given that MMQ doesn’t last very long as is, this is far from ideal but it seems to be quite pleasant anyway.

It is a fine white powder which is highly insoluble in water and 50:50 isopropanol water. Like MMQ it is not bitter at all, and seems to be less sour too. By comparison, etaqualone is slightly bitter, but still nothing compared to phenethylamines, for example.

When vaporised I found there was a faint taste of chlorine. I’m not exactly sure what caused this but it is not something I noticed before, but it put me off instantly.

The threshold effects are very minor at about 5mg, but are noticeable. Sublingual should not be ideal with this, as the solubility is low, but it does seem to work. Holding 10mg for as long as possible, I noticed effects within a few minutes, a pleasant disorientation. After 15 minutes effects did not seem to be intensifying, remaining at a subtle but pleasant level. After 45 minutes the effects were clearly waning and I went for another 15mg sublingually. Again, the effects came on again quickly and began to fade after 25 minutes.

At this point I climbed into bed and quickly fell into a pleasant sleep.

Overall a lovely compound, but realistically too short-lived to gain much popularity.



Methylmethaqualone (MMQ) is a potent analogue of methaqualone (MQ), a depressant in the quaalude class. Methaqualone was popular recreationally until it was phased out of medical use in favour of the safer benzodiazepines. Since then supply has declined but recently a number of analogues have been produced.

MMQ is notably more potent than MQ, with little research surrounding its use in humans. Tests in mice indicated an increased tendency towards seizure and equipotency. Human experimentation has confirmed that seizures are possible at high doses.

Some concerns have been raised that its seizure induction suggests may be an AMPA agonist, meaning it would be excitotoxic and have an anti-nootropic effect, but having tried it once before hearing this and noticing no such effects I do not suspect this to be significant, if it is true at all.

Dosage: 12mg vaporised, 20mg sublingual, ~60mg(?) oral

Duration: 30 minutes vaporised, 90 minutes sublingual.

Description: A short active sedative with pleasant effects. Nothing particularly special


I initially vaporised to get a feel for the effective dose. I loaded 12mg into the vaporiser. The HCl salt vaporises easily without burning. Constant inhalation is easy but large hits are horrible to inhale. The effects come on quickly and are typical of depressants. I noticed that it is somewhat more mood-lifting than benzodiazepines and has a bit more of a fun quality to it aside from the stardard anxiolytic effects of benzos. When I noticed my nose was bleeding I stopped vaporising immediately. I am not sure of the cause. The total duration can’t be more than 30 minutes.

The second trial was 18mg sublingually. The compound has a peculiar taste – not very bitter but almost sour, with a sting-y sort of taste. The after-taste is similarly odd. The effects come to a peak within around 20 minutes and are as before, pleasant. This peaked at about 20 mins and started to fade after 30. I would say it lasted about 2 hours total but I redosed 22mg after 1.5 hours as I found the original underwhelming. There were no adverse effects from this.

I tried this at a later date orally with no sublingual absorption. I initially dose 15mg, and while it was noticeable, it was very subtle. I added another two 15mg doses over the next hour and a half, but these added little. Fifteen minutes after these I added another 30mg which had a similarly small effect. I stopped at this point. This surprised me from the same batch as before, I wonder if the short duration indicates a fast metabolism and oral absorption is simply not fast enough to keep up with this in low doses. More research required.

Overall I would rate it well, if it is indeed not harmful. It is very pleasant with a duration just long enough to be suitable for a social setting.